A biosensor for detecting changes in cognitive processing based on nonlinear systems analysis.

نویسندگان

  • G Gholmieh
  • W Soussou
  • S Courellis
  • V Marmarelis
  • T Berger
  • M Baudry
چکیده

A new type of biosensor, based on hippocampal slices cultured on multielectrode arrays, and using nonlinear systems analysis for the detection and classification of agents interfering with cognitive function is described. A new method for calculating first and second order kernel was applied for impulse input-spike output datasets and results are presented to show the reliability of the estimations of this parameter. We further decomposed second order kernels as a sum of nine exponentially decaying Laguerre base functions. The data indicate that the method also reliably estimates these nine parameters. Thus, the state of the system can now be described with a set of ten parameters (first order kernel plus nine coefficients of Laguerre base functions) that can be used for detection and classification purposes.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Indirect Adaptive Interval Type-2 Fuzzy PI Sliding Mode Control for a Class of Uncertain Nonlinear Systems

Controller design remains an elusive and challenging problem foruncertain nonlinear dynamics. Interval type-2 fuzzy logic systems (IT2FLS) incomparison with type-1 fuzzy logic systems claim to effectively handle systemuncertainties especially in the presence of disturbances and noises, but lack aformal mechanism to guarantee performance. In contrast, adaptive sliding modecontrol (ASMC) provides...

متن کامل

An approach to fault detection and correction in design of systems using of Turbo ‎codes‎

We present an approach to design of fault tolerant computing systems. In this paper, a technique is employed that enable the combination of several codes, in order to obtain flexibility in the design of error correcting codes. Code combining techniques are very effective, which one of these codes are turbo codes. The Algorithm-based fault tolerance techniques that to detect errors rely on the c...

متن کامل

Design and Simulation of a Fluidic Micro-Bio-Sensor Based on Resonator Array

In this paper, a fluidic biosensor with possibility to fabricate by Micro-Electro-Mechanical Systems (MEMS) technology is proposed for biomedical mass detection and lab-on-chip applications. This is designed by electromechanical coupling of harmonic micromechanical resonators with harmonic springers as a mechanical resonator array. It can disperse mechanical wave along the array by electrostati...

متن کامل

Modeling Structural Relationships of Meta-Cognitive Situations with Tendency to Virtual Networks through Mediating of Emotional Processing in Gifted Students

Background: Cyberspace covers many aspects of human life and tendency to cyberspace can be influenced by cognitive and emotional dimensions. Thus, the aim of this study was modeling structural relationships of meta-cognitive situations with tendency for virtual networks through mediating emotional processing in gifted students. Methods: The research method was descriptive-correlation and in pa...

متن کامل

Investigation of seismic damage index due to water level changes in reservoir through nonlinear dynamic analysis under Far-Fault and Near-Fault ground motions

In this study, reservoir water level effects on nonlinear dynamic response of concrete gravity dams are investigated. For this purpose, the nonlinear behavior of the dam concrete is captured using the concrete damage plasticity (CDP) on the non associated flow rule assumption. Water in the reservoir is represented by the Lagrangian (displacement-based) fluid finite elements. The program ABAQUS ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Biosensors & bioelectronics

دوره 16 7-8  شماره 

صفحات  -

تاریخ انتشار 2001